Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet-Induced Obese and Streptozotocin-Induced Diabetic Mice


The aim of the present study was to establish antiobesity and antidiabetic activities of the seeds of Phalaris canariensis.

The present study, which represents the first report on the antiobesity and lipid-lowering effects of seeds of P. canariensis in obese animals, has shown that there was a significant difference in the body weights between the high-fat and normal diet groups; no significant difference in the daily food intake between groups was observed. The high-fat diet groups continuously consumed similar quantities of food, regardless of the higher calories content in the diet. As a result, the caloric intake was raised in the high-fat diet group compared to the normal group counterpart. The supplementation of obese rats with AL-H at 400 mg/kg conversely causes a remarkable reduction of body weights compared to the untreated obese group. The findings demonstrated that AL-H is capable of preventing body weight gain and showed a significant reduction in their body weight after 4 weeks of treatment. 

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Evidence-Based Complementary and Alternative Medicine

Volume 2014, Article ID 145901, 13 pages

Received 11 May 2013; Revised 21 November 2013; Accepted 27 November 2013; Published 9 January 2014

Academic Editor: Musa T. Yakubu

Copyright © 2014 Rosa Martha Perez Gutierrez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.